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CaMKII antibody

CaMKII antibody

Catalog Number: orb147059

DispatchUsually dispatched within 2-3 weeks
$ 529.00
Catalog Numberorb147059
CategoryAntibodies
DescriptionMouse monoclonal to CaMKII (FITC). CaMKII is an important member of calcium/calmodulin- activated protein kinase family, functioning in neural synaptic stimulation and T-cell receptor signaling. CaMKII is expressed in many different tissues but is specifically found in the neurons of the forebrain and its mRNA is found within the dendrites and the soma of the neuron. The CaMKII that is found in the neurons consist of two subunits of 52 (termed alpha genes) and 60 kDa (beta genes). CaMKII has catalytic and regulatory domains, as well as an ATP-binding domain, and a consensus phosphorylation site (3-7). The binding of Ca2+ auto inhibitory effect and activates the kinase. /calmodulin to its regulatory domain releases its This kinase activation results in auto phosphorylation at threonine 286. The threonine phosphorylation state of CaMKII can be regulated through PP1/PKA. Whereas PP1 (protein phosphatase 1) dephosphorylates phospho-CaMKII at Thr286, PKA (protein kinase A) prevents this dephosphorylation. Auto phosphorylation also enables CaMKII to attain an enhanced affinity for NMDA receptors in postsynaptic densities (10-12)..
Species/HostMouse
ClonalityMonoclonal
Clone Number22B1
Tested applicationsELISA, ICC, IHC, IP, WB
ReactivityHuman, Mouse, Rat
IsotypeIgG1
ImmunogenSynthetic peptide
Concentration1 mg/ml
Dilution rangeWB (1:1000), IHC (1:100), ICC/IF (1:1000)
ConjugationFITC
TargetCaMKII
Entrez25400
UniProt IDP11275
NCBINP_037052.1
StorageConjugated antibodies should be stored at 4°C
Buffer/PreservativesPBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Alternative namesCSAID Binding protein 1 antibody, CSBP1 antibody,
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NoteFor research use only
Application notes1 µg/ml was sufficient for detection of 0.2 µg CamKII by colorimetric immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary.
Expiration Date12 months from date of receipt.
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