C 101248

SKU: orb1979911

Description

C 101248 (KCNK13-IN-1) is a potent and selective inhibitor of the THIK-1 (KCNK13) potassium channel. It suppresses IL-1β release in vitro and is a useful research tool for investigating neuroinflammation mechanisms in models of neurodegenerative disease.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 361368-24-3
• MW: 292.3
• Purity: 99.31%
• Formula: C₁₅H₁₂N₆O
• SMILES: N=1C=CC(=CC1)CN2C(=NC3=CC=CC=C32)C4=NON=C4N
• Target: Potassium Channel
• Solubility: DMSO:8 mg/mL (27.37 mM)

Bioactivity

• Target IC50:
  THIK-1 (mouse):~50 nM|THIK-1 (human):~50 nM
• In Vitro:
  C 101248 showed a concentration-dependent inhibition of both mouse and human THIK-1 (IC50: ~50 nM) and was inactive against K2P family members TREK-1 and TWIK-2, and Kv2.1. Whole-cell patch-clamp recordings of microglia from mouse hippocampal slices showed that C 101248 potently blocked both tonic and ATP-evoked THIK-1 K currents.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

C101248, KCNK13-IN-1

Compound Identifiers

PubChem CID

723233