BRAF Antibody

• Catalog Number: orb1732641
• Category: Antibodies
• Description: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Frequently mutated in thyroid cancers, skin melanomas and at lower frequency in a wide range of human cancers. An activating mutation, mimicking phosphorylation of the activation loop, is seen in 60% of malignant melanoma samples. Raf mutations are generally exclusive to Ras activating mutations.
• Species/Host: Mouse
• Clonality: Monoclonal
• Clone Number: 7B10
• Tested applications: WB
• Reactivity: Human, Mouse
• Isotype: Mouse IgG2a
• Immunogen: Purified recombinant human B Raf protein fragments expressed in E.coli.
• Concentration: 1mg/ml
• Dilution range: WB: 1/500-1/1000
• Conjugation: Unconjugated
• MW: Calculated MW: 84 kDa; Observed MW: 87 kDa
• Entrez: 673
• UniProt ID: P15056
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Buffer/Preservatives: Liquid in PBS containing 50% glycerol, 0.5% rAlbumin and 0.02% sodium azide, pH 7.3.
• Alternative names: BRAF; BRAF1; RAFB1; Serine/threonine-protein kinas
• Note: For research use only
• Expiration Date: 12 months from date of receipt.