Benzquinamide hydrochloride

SKU: orb1297829

Description

Benzoquinamide hydrochloride is a small molecule antiemetic agent that also elevates arterial pressure through peripheral vasoconstriction. It is utilized in pharmacological research to study emesis control and cardiovascular responses in both in vitro receptor assays and in vivo animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 113-69-9
• MW: 440.96
• Purity: 99.56% (May vary between batches)
• Formula: C₂₂H₃₃ClN₂O₅
• SMILES: CC(OC1CC2C3=CC(OC)=C(OC)C=C3CCN2CC1C(N(CC)CC)=O)=O.Cl
• Target: Others,Adrenergic Receptor
• Solubility: DMSO:55 mg/mL (124.73 mM)

Bioactivity

• In Vivo:
  Benzquinamide (0.5 to 5 mg/kg; i.v.) caused tachycardia, elevated blood norepinephrine levels, frequent ventricular arrhythmias, and brief hypotension. Ganglionic blockade by hexamethonium prior to administration of benzquinamide prevented the tachycardia and alterations in norepinephrine levels but prolonged the period of hypotension. In isolated mesenteric arterial preparations, benzquinamide interfered with the contractile force generated by potassium chloride, norepinephrine, and prostaglandin F2 alpha.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3-carbamoyl-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,11-dimethoxy-2H-benzo[a]quinolizin-2-yl acetate hydrochloride, Benzoquinamide Hydrochloride, Benzquinamide hydrochloride

Compound Identifiers

PubChem CID

101584