BChE/HDAC6-IN-2 is a potent dual inhibitor of butyrylcholinesterase and histone deacetylase 6, exhibiting neuroprotective, ROS-scavenging, and anti-tau phosphorylation properties. This small molecule is a valuable research tool for investigating mechanisms and therapeutic strategies in neurodegenerative and neuroimmune disease models, both in vitro and in vivo.