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Catalog Number | orb613859 |
---|---|
Category | Antibodies |
Description | Mouse monoclonal antibody to BACE2 |
Species/Host | Mouse |
Clonality | Monoclonal |
Clone Number | 1/ 9 |
Tested applications | IHC, WB |
Reactivity | Human |
Isotype | IgG1 |
Immunogen | Human BACE2 244–333. |
Concentration | 1 mg/ml |
Purity | Purified |
Conjugation | Unconjugated |
Target | BACE2 |
UniProt ID | Q9Y5Z0 |
Storage | Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. |
Buffer/Preservatives | PBS with 0.02% Proclin 300. |
Alternative names | Beta-secretase 2; Aspartic-like protease; Aspartyl Read more... |
Note | For research use only |
Application notes | The antibody binds specifically to BACE2, an enzyme responsible for the proteolytic cleavage of amyloid precursor protein (APP). The protein is cleaved between residues 690 and 691, leading to the formation of beta-cleaved soluble APP and a C-terminal membrane bound fragment (CTFβ). The latter is then cleaved by gamma-secretase to generate amyloid beta peptide. BACE is the rate-limiting enzyme in the pathway, and is a potential target in the treatment of Alzheimer's Disease (AD),a neurodegenerative disorder characterised by amyloid beta plaques within the brain. The BACE2 protein is encoded in chromosome 21, in a region critical for the development of Down's Syndrome, and may play a role in the amyloid beta deposition in the disease. |
Expiration Date | 12 months from date of receipt. |
ELISA, IHC-P, WB | |
Mouse, Rat | |
Human | |
Rabbit | |
Polyclonal | |
Unconjugated |
ELISA, IHC-P, WB | |
Human, Mouse, Rat | |
Rabbit | |
Polyclonal | |
Unconjugated |
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