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BACE2 antibody

BACE2 antibody

Catalog Number: orb613859

DispatchUsually dispatched within 5-10 working days
$ 531.00
Catalog Numberorb613859
CategoryAntibodies
DescriptionMouse monoclonal antibody to BACE2
Species/HostMouse
ClonalityMonoclonal
Clone Number1/ 9
Tested applicationsIHC, WB
ReactivityHuman
IsotypeIgG1
ImmunogenHuman BACE2 244–333.
Concentration1 mg/ml
PurityPurified
ConjugationUnconjugated
TargetBACE2
UniProt IDQ9Y5Z0
StorageStore at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
Buffer/PreservativesPBS with 0.02% Proclin 300.
Alternative namesBeta-secretase 2; Aspartic-like protease; Aspartyl
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NoteFor research use only
Application notesThe antibody binds specifically to BACE2, an enzyme responsible for the proteolytic cleavage of amyloid precursor protein (APP). The protein is cleaved between residues 690 and 691, leading to the formation of beta-cleaved soluble APP and a C-terminal membrane bound fragment (CTFβ). The latter is then cleaved by gamma-secretase to generate amyloid beta peptide. BACE is the rate-limiting enzyme in the pathway, and is a potential target in the treatment of Alzheimer's Disease (AD),a neurodegenerative disorder characterised by amyloid beta plaques within the brain. The BACE2 protein is encoded in chromosome 21, in a region critical for the development of Down's Syndrome, and may play a role in the amyloid beta deposition in the disease.
Expiration Date12 months from date of receipt.
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