ATF4-IN-1

• Catalog Number: orb2566940
• Category: Small Molecules
• Description: ATF4-IN-1 (Compound 21) serves as an inhibitor of ATF4, demonstrating effective suppression of ATF4 expression in Thapsigargin-stimulated HEK-293T cells with an IC50 of 32.43 nM. Compared to ISRIB, ATF4-IN-1 shows enhanced activity and exhibits minimal cytotoxicity, with an IC50 of 96 μM in HEK-293T cells. This compound is utilized in the investigation of neurodegenerative diseases [1].
• CAS Number: 2991057-76-0
• Purity: 98.00%
• MW: 486.35
• SMILES: ClC=1C=C2C=C(OC2=CC1)C=3OC(=NN3)[C@@H]4CC[C@@H](NC(COC5=CC=C(Cl)C=C5)=O)CC4
• Formula: C₂₄H₂₁Cl₂N₃O₄
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.