8-Oxo-dGTP

• Catalog Number: orb64224
• Category: Tools
• Description: 8-Hydroxy-dGTP
• CAS Number: 139307-94-1
• Concentration: 10 mM-11 mM
• Form/Appearance: solution in water; Color: colorless to slightly yellow; pH: 7.5 ± 0.5
• Purity: ≥ 95% (HPLC)
• MW: Theoretical MW: 523.18 g/mol (free acid); Detected MW: 522.99 g/mol (free acid)
• SMILES: Nc1[nH]c(=O)c2c(n(c(=O)[nH]2)[C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)C2)n1
• Formula: C₁₀H₁₆N₅O₁₄P₃
• Storage: store at -20 °C
• Note: For research use only
• Application notes: Influence on base excision repair; Influence on erroneous incorporation by DNA-polymerases; Hydrolysis to 8-oxo-dGMP by E.-coli MutT; Triggering cell senescence through formation of ROS. ; Spectroscopic Propertie: λmax 245 nm, ε 12.3 L mmol-1 cm-1 (Tris-HCl, pH 7.5).
• Expiration Date: 12 months from date of receipt.

References

Xiangxiang Wang, Yuyu Zhao, Zhaohua Hou, Xiaoxu Chen, Shuangying Jiang, Wei Liu, Xin Hu, Junbiao Dai, Guangh Large-scale pathway reconstruction and colorimetric screening accelerate cellular metabolism engineering Metabolic Engineering, 80, 107-118 (2023)

PubMed: 37717647

Chemical structure of 8-Oxo-dGTP

Chemical structure of 8-Oxo-dGTP