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Product Overview
Product Name 8-Oxo-dGTP
Catalog Number orb64224
ConjugationUnconjugated
Tested applicationsHPLC, NMR
Target 8-Oxo-dGTP
Product Properties
Form/Appearance clear aqueous solution, pH 7.5 +0.5
Concentration 10 mM
Storage store at -20°C Short term exposure (up to 1 week cumulative) to ambient temperature possible. If stored as recommended, Biorbyt guarantees optimal performance of this product for 12 months after date of delivery.
Note For research use only.
Purity > 95 % (HPLC)
Formula C10H16N5O14P3 (free acid)
MW 523.18 g/mol (free acid)
CAS Number [139307-94-1]
Chemical Name [[[(2R,3S,5R)-5-(2-amino-6,8-dioxo-3,7-dihydropurin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] hydrogen phosphate
PubChem CID CID 56927775
Product Description

8-oxo-dGTP is a product of oxidative modification of dGTP that can be wrongly incorporated into DNA, causing AT-->CG mutations. 8-Oxo-dG DNA lesions are formed in the cell by reactive oxygen species.

Application Notes
Application Notes Λmax 245 nm; ε 12.3 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Influence on base excision repair[1]
Influence on erroneous incorporation by DNA-polymerases[2]
Hydrolysis to 8-oxo-dGMP by E.-coli MutT[3]
Triggering cell senescence through formation of ROS[4]
Solubility (25°C)
In vitro
Water>10mM
Validation Images
Chemical structure of 8-Oxo-dGTP
Chemical structure of 8-Oxo-dGTP
Chemical structure of 8-Oxo-dGTP
Chemical structure of 8-Oxo-dGTP
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